Inspiregifts.org: Inspired Gifts is an innovative program that allows you to purchase real, lifesaving products--like blankets, bednets and vaccines--to be shipped directly to one of over 150 countries where UNICEF is saving children's lives.
Audreybag.com: The Audey Hepburn Children's Fund has begun producing a limited collection of beautifully made handbags showing Hepburn's image. All profits, after production costs, will go to the fund.
Heifer.org: Heifer's mission is to work with communities around the world to end hunger and poverty and care for the earth, and they are currently have several giving opportunities that help achieve that mission.
World Vision: My favorite one for many years, you can give a gift in honor of someone you love and respect.